Fibromyalgia
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Here we see proof that ATP is lowered in individuals suffering the relatively mysterious condition known as fibromyalgia.

[6-16]

Glycolysis abnormalities in fibromyalgia.

Eisinger J, Plantamura A, Ayavou T.

Department of Rheumatic Diseases—Centre Hospitalier, Toulon, France.

OBJECTIVE: Primary fibromyalgia (FM) is a painful condition, generally treated by analgesic drugs and antidepressants, which has been associated with hyperpyruvicemia and reduced high energy phosphate in muscle. Biological investigations were performed in patients with FM to determine whether this syndrome was related to carbohydrate metabolism impairment. METHOD: Glycolysis was studied in 25 patients with FM, 10 patients with hypothyroidism (HO), 15 patients with osteoarticular chronic pain (OACP), and 36 healthy controls. Laboratory studies were performed on whole blood (pyruvate), erythrocytes (pyruvate kinase, 2-3 diphosphoglycerate, glyceraldehyde phosphodeshydrogenase, adenosine triphosphate), plasma and serum (lactate at rest and after forearm ischemic exercise, lactico deshydrogenase iso-enzymes). RESULTS: Comparisons between study groups and controls demonstrated increased pyruvate and decreased lactate production in FM and HO; adenosine triphosphate and muscular isoenzymes of lacticodeshydrogenase were decreased in FM only; glycolysis was not significantly impaired in OACP. CONCLUSIONS: These findings provide support that FM is associated with biochemical abnormalities which require appropriate metabolic therapy.

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In medicine we are trained to look for certain well mapped out "trigger points" when diagnosing fibromyalgia. They sampled tissue form these "trigger points", and found they indeed were depleted of ATP. This is why, in our clinical experience, we see that patients who take the combination of supplements found in CardioFuel find relief from their terrible fibromyalgia symptoms, as it rapidly increases ATP concentration.

[6-5]

Reduced high-energy phosphate levels in the painful muscles of patients with primary fibromyalgia.

Bengtsson A, Henriksson KG, Larsson J.

Muscle energy metabolism was studied by chemical analysis of biopsy samples from: 1) trigger points in the trapezius muscle from 15 patients with primary fibromyalgia (PF), 2) nonpainful, anterior tibial muscle from 6 patients with PF, and 3) the trapezius muscle from 8 healthy controls. We found a decrease in the levels of adenosine triphosphate, adenosine diphosphate, and phosphoryl creatine, and an increase in the levels of adenosine monophosphate and creatine, in the trapezius muscles from the patients. These findings support the notion that the pain in patients with PF is of muscular origin.

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Case study where a woman suffering fibromyalgia found relief by taking ribose. There is more discussion about some proof that lowered ATP levels may be an important part of this mysterious syndrome.

[6-19]

Benefit of ribose in a patient with fibromyalgia.

Gebhart B, Jorgenson JA.

Department of Pharmacy Services, University Hospitals and Clinics, Salt Lake City, Utah, USA.

Ribose was added to the existing treatment regimen of a woman with fibromyalgia, resulting in a decrease in symptoms. It has been postulated that patients with fibromyalgia may have an alteration in muscle adenine nucleotide metabolism, leading to depleted energy reserves and an imbalance in cellular adenosine 5'-triphosphate:adenosine 5'-diphosphate:adenosine 5'-monophosphate (ATP:ADP:AMP) ratios with an abnormal energy charge. As a key component in adenine nucleotide synthesis, ribose supplementation may be useful in such patients.

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